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WWOX regulates p53 function, model of action and scenarios. I. WWOX modulates the DNA damage response pathway, antagonizes genomic instability and inhibits loss of p53. II. WWOX modulates ER expression and function, which in turn positively or negatively affects p53. III. WWOX inhibits the epithelial-to-mesenchymal transition (EMT). p53 is known to inhibit both genomic instability and EMT.
