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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 Dec 11;127:165–173. doi: 10.1016/j.yjmcc.2018.12.003

Fig. 4.

Fig. 4.

Thin filament motion on thick filaments isolated from HCM (n=4) and donor (n=4) heart samples. (A) Fraction of thin filaments moving on thick filament isolated from the donor (black; pCa50=6.6±0.1) and HCM heart samples (red; pCa50=6.3±0.1) versus calcium concentration. The pCa50 differed, P<0.05. (B and C) Displacement versus time traces for thin filaments sliding on thick filament isolated from (B) donor and (C) HCM heart samples at pCa 4 demonstrating 2 phases of velocity (n=15 filaments). (D) Average ± SEM velocities of thin filaments sliding on the tips and within the C-zones of thick filaments isolated from donor (black, n=50 filaments) and HCM (red, n=57 filaments) heart samples. Thick filament tip and C-zone velocities predicted from an analytical model using donor heart data with a theoretical 40% reduction in MyBP-C content. *P<0.01