Table 1. Summarizes the pathologic, molecular and cytological characteristics of 46 surgical resection specimens of pancreatic cystic lesions (PCLs).
| Cyst Type- grade | KRAS | GNAS | Other genes | Cytology result | Algorithm diagnosis | Molecular diagnosis* |
|---|---|---|---|---|---|---|
| 1- IPMN - LG | p.G12V | NEG | NEG | NEG | mPCN | mPCN |
| 2- IPMN - LG | p.G12V | p.R201C | NEG | A/S | mPCN | mPCN |
| 3- IPMN - LG | p.G12V | p.R201C | NEG | A/S | mPCN | mPCN |
| 4- IPMN - LG | p.G12V | p.R201H | NEG | ND | mPCN | mPCN |
| 5- IPMN - LG | p.G12V | NEG | NEG | ND | mPCN | mPCN |
| 6- IPMN - LG | p.G12R | NEG | NEG | A/S | mPCN | mPCN |
| 7- IPMN - LG | p.G12R | p.R201H | NEG | A/S | mPCN | mPCN |
| 8- IPMN - LG | p.G12A | p.R201H | NEG | NEG | mPCN | mPCN |
| 9- IPMN - LG | p.G12R | NEG | NEG | NEG | mPCN | mPCN |
| 10- IPMN - LG | NEG | NEG | NEG | ND | mPCN | nmPCL |
| 11- IPMN - LG | p.G12V | p.R201C | NEG | ND | mPCN | mPCN |
| 12- IPMN - LG | p.Q61H | p.R201H | NEG | ND | mPCN | mPCN |
| 13- IPMN - MG | p.G12D | NEG | NEG | NEG | mPCN | mPCN |
| 14- IPMN - MG | p.G12D | p.R201C | APC | NEG | mPCN | mPCN |
| 15- IPMN - MG | p.G12V | p.R201C | CDKN2A | POS | mPCN | mPCN |
| 16- IPMN - MG | p.G12A p.G12T | p.R201C p.R201H | NEG | ND | mPCN | mPCN |
| 17- IPMN - MG | NEG | p.R201C | NEG | ND | mPCN | mPCN |
| 18- IPMN - HG | p.G12V | NEG | TP53, PIC3CA | A/S | mPCN | mPCN |
| 19- IPMN - HG | NEG | NEG | BRAF | NEG | mPCN | mPCN |
| 20- MCN - LG | p.Q61H | NEG | NEG | NEG | mPCN | mPCN |
| 21- MCN - LG | NEG | NEG | NEG | ND | mPCN | nmPCL |
| 22- MCN - LG | p.G12D | NEG | NEG | A/S | mPCN | mPCN |
| 23- MCN - LG | p.G12D | NEG | NEG | NEG | mPCN | mPCN |
| 24- MCN - LG | NEG | NEG | NEG | ND | mPCN | nmPCL |
| 25- MCN - MG | p.G12D | NEG | TP53 | A/S | mPCN | mPCN |
| 26- MCN - MG | p.G12V | NEG | NEG | NEG | mPCN | mPCN |
| 27- MCN - MG | NEG | NEG | NEG | NEG | mPCN | nmPCL |
| 28- MCN - MG | p.G12D | NEG | NEG | ND | mPCN | mPCN |
| 29- PDA | p.G12R | NEG | TP53 | POS | mPCN | mPCN |
| 30- PDA | p.G12V | NEG | TP53, SMAD4 | POS | mPCN | mPCN |
| 31- PDA | p.G12D | NEG | SMAD4 | POS | mPCN | mPCN |
| 32- PDA | p.G12D | NEG | RB1, SMAD4, PTEN | POS | mPCN | mPCN |
| 33- PDA | p.G12D | NEG | TP53 | POS | mPCN | mPCN |
| 34- PDA | NEG | p.R201H | SMAD4, TP53 | POS | mPCN | mPCN |
| 35- PDA | p.Q61C | p.R201C | TP53, CDKN2A | POS | mPCN | mPCN |
| 36- PDA | p.G12D | p.R201H | NEG | NEG | mPCN | mPCN |
| 37- SCA | NEG | NEG | VHL | NEG | mPCN | nmPCL |
| 38- SCA | NEG | NEG | VHL | NEG | nmPCL | nmPCL |
| 39- PNET | NEG | NEG | NEG | A/S | mPCN | nmPCL |
| 40- PNET | NEG | NEG | ATM | POS | mPCN | nmPCL |
| 41- PNET | NEG | NEG | NEG | A/S | mPCN | nmPCL |
| 42- Pseudocyst/CP | NEG | NEG | NEG | NEG | nmPCL | nmPCL |
| 43- Pseudocyst/CP | NEG | NEG | NEG | NEG | nmPCL | nmPCL |
| 44- Pseudocyst/CP | p.G12D | NEG | NEG | NEG | mPCN | mPCN |
| 45- Pseudocyst/CP | NEG | NEG | NEG | NEG | nmPCL | nmPCL |
| 46- Pseudocyst/CP | NEG | NEG | NEG | NEG | nmPCL | nmPCL |
(CP: chronic pancreatitis, IPMN: Intraductal papillary mucinous neoplasm, MCN: Mucinous cystic neoplasm, mPCN: mucinous pancreatic cystic neoplasm, nmPCN: non-mucinous pancreatic cystic neoplasm, PDA: Pancreatic ductal carcinoma, PNET: Pancreatic neuroendocrine tumor, SCA: Serous cystadenoma, A/S: atypical/suspicious, HG: high-grade, LG: low-grade, MG: intermediate grade, ND: non-diagnostic, NEG: Negative, POS: positive)
*Based on the presence or absence of any of the following genes: BRAF, KRAS, GNAS, PIK3CA, CDKN2A, PTEN, SMAD4, and TP53.