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. 2019 Apr 24;11(4):e4538. doi: 10.7759/cureus.4538

Table 3. ABPA Staging, Radiographic Findings, and Corresponding IgE Levels.

ABPA: allergic bronchopulmonary aspergillosis; IgE: immunoglobulin E; CT: computed tomography.

Stage Description Radiographic Findings Total IgE Concentration
Stage I: acute The patient is diagnosed with ABPA. Some features such as Aspergillus-specific IgE, radiological abnormalities, peripheral blood eosinophilia, and Aspergillus-specific serum precipitins may be seen [12]. There may be homogenous infiltrates, mucus plugging, lobar consolidation or collapse, “tree-in-bud” appearance, bronchiectasis (see Figure 1) [8]. Overall elevated [8]
Stage II: remission Asymptomatic patient with underlying controlled asthma but no new radiological infiltrates and no rise in total IgE for a minimum of six months [12]. No infiltrates are seen [8]. Normal or elevated IgE level but less than stage I level [8].
Stage III: exacerbation New pulmonary infiltrates appear on x-ray with peripheral blood eosinophilia and double the remission level IgE levels [12]. The same findings as seen in acute stage  [8]. Elevated IgE levels usually double the level of stage II [8].
Stage IV: steroid-dependent asthma Patients become dependent on corticosteroid treatment and are unable to completely taper off from it [12]. No infiltrates are seen. There can be atelectasis or hyperinflation from asthma [8]. If exacerbation occurs then the findings will resemble stage I [8]. Normal or elevated IgE level [8].
Stage V: end-stage fibrotic disease Chest x-ray and CT scans will show irreversible fibrosis and chronic cavitation. Despite this, serological parameters are usually negative [12]. There is lung scarring, hyperinflation, chronic infiltrates, fibrosis or cavities or fibrocavitary findings [8]. Normal or elevated IgE level [8].