Stage |
Description |
Radiographic Findings |
Total IgE Concentration |
Stage I: acute |
The patient is diagnosed with ABPA. Some features such as Aspergillus-specific IgE, radiological abnormalities, peripheral blood eosinophilia, and Aspergillus-specific serum precipitins may be seen [12]. |
There may be homogenous infiltrates, mucus plugging, lobar consolidation or collapse, “tree-in-bud” appearance, bronchiectasis (see Figure 1) [8]. |
Overall elevated [8] |
Stage II: remission |
Asymptomatic patient with underlying controlled asthma but no new radiological infiltrates and no rise in total IgE for a minimum of six months [12]. |
No infiltrates are seen [8]. |
Normal or elevated IgE level but less than stage I level [8]. |
Stage III: exacerbation |
New pulmonary infiltrates appear on x-ray with peripheral blood eosinophilia and double the remission level IgE levels [12]. |
The same findings as seen in acute stage [8]. |
Elevated IgE levels usually double the level of stage II [8]. |
Stage IV: steroid-dependent asthma |
Patients become dependent on corticosteroid treatment and are unable to completely taper off from it [12]. |
No infiltrates are seen. There can be atelectasis or hyperinflation from asthma [8]. If exacerbation occurs then the findings will resemble stage I [8]. |
Normal or elevated IgE level [8]. |
Stage V: end-stage fibrotic disease |
Chest x-ray and CT scans will show irreversible fibrosis and chronic cavitation. Despite this, serological parameters are usually negative [12]. |
There is lung scarring, hyperinflation, chronic infiltrates, fibrosis or cavities or fibrocavitary findings [8]. |
Normal or elevated IgE level [8]. |