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. 2019 Jun 6;7(2):e13303. doi: 10.2196/13303

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©Najmeh Khalili-Mahani, Bob De Schutter. Originally published in JMIR Serious Games (http://games.jmir.org), 06.06.2019.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Serious Games, is properly cited. The complete bibliographic information, a link to the original publication on http://games.jmir.org, as well as this copyright and license information must be included.

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The summary of results from a neuroimaging experiment using a game-like task (MIST). We compared effects of doing metal arithmetics under time- and observer-pressure on brain and stress response in 2 groups of healthy young and older adults. Group differences in personality (Questionnaire of Competence and Control), brain activation (hemodynamic response to experimental versus control), and stress (cortisol) emerged, potentially because of differences in perception of the stressful nature of the task.