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. 2019 Jun 25;14(6):e0218203. doi: 10.1371/journal.pone.0218203

Fig 2. Engineered disulfides slow the rate of thioester hydrolysis.

Fig 2

(A) Model of TED (green), CUB (blue) and MG8 (yellow) domains for TEP1*S1, with engineered disulfide bonds (red) K973C/Q1228C, M801C/V1102C and K969C/Y1275C. (B) Rate of thioester hydroylsis for cleaved forms of TEP1*S1, TEP1*R1, and three engineered disulfide mutants of TEP1*S1.