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. 2019 Jun 13;15(6):e1008158. doi: 10.1371/journal.pgen.1008158

Fig 7. The responses of the IPCs to PDF and sNPF are absent in the PDF receptor mutant han, but only the response to PDF is mediated by the PDF receptor.

Fig 7

(A-D) Live imaging in han mutants expressing a cAMP sensor in their IPCs (han; dilp2(p)>Epac1camps). In the mutant background, the effects of both neuropeptides are abolished. (A-B) Maximum inverse FRET changes from 100–1000 s. Short-term responses are all abrogated in han flies. (C-D) Maximum inverse FRET changes from 100–200 s. (E-H) Live imaging in han mutants with the PDF receptor rescued in the IPCs. The expression of han in the IPCs induces very strong responses to PDF but not to sNPF (E-F) Maximum inverse FRET changes from 100–1000 s. (G-H) Maximum inverse FRET changes from 100–200 s. Labeling as in Fig 4.