Table 1. Genomic risk loci.
Genomic Locus | rsID | chr | pos | Nearest Gene | A1 | A2 | MAF | r2 | beta | se | P |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | rs10888692 | 1 | 50991473 | FAF1 | C | G | 0.4301 | 1 | -0.0143 | 0.0025 | 5.30E-09 |
2 | rs197422 | 1 | 112000000 | KCND3 | C | A | 0.3794 | 1 | -0.015 | 0.0025 | 2.00E-09 |
3 | rs59898460 | 1 | 150000000 | LINC00568 | T | C | 0.4044 | 1 | 0.0169 | 0.0025 | 9.20E-12 |
4 | rs12071912 | 1 | 243000000 | RP11-261C10.3 | C | T | 0.3163 | 1 | -0.0153 | 0.0026 | 5.30E-09 |
5 | rs4852567 | 2 | 80703379 | CTNNA2 | A | G | 0.2834 | 1 | 0.0149 | 0.0027 | 4.30E-08 |
6 | rs7628207 | 3 | 49754970 | RNF123:AMIGO3:GMPPB | T | C | 0.1766 | 1 | 0.0195 | 0.0032 | 8.40E-10 |
7 | rs28428925 | 3 | 107000000 | BBX | G | A | 0.1365 | 1 | -0.0214 | 0.0035 | 1.40E-09 |
8 | rs6770476 | 3 | 136000000 | STAG1 | C | T | 0.289 | 1 | -0.0154 | 0.0027 | 9.40E-09 |
9 | rs34811474 | 4 | 25408838 | ANAPC4 | G | A | 0.2285 | 1 | 0.0192 | 0.0029 | 2.70E-11 |
10 | rs13135092 | 4 | 103000000 | SLC39A8 | A | G | 0.08071 | 1 | -0.0328 | 0.0044 | 1.50E-13 |
11 | rs13136239 | 4 | 141000000 | MAML3 | G | A | 0.3508 | 1 | 0.0141 | 0.0026 | 3.60E-08 |
12 | rs6869446 | 5 | 65570607 | RP11-305P14.1 | T | C | 0.3861 | 1 | -0.0144 | 0.0025 | 9.50E-09 |
13 | rs1976423 | 5 | 104000000 | RP11-6N13.1 | A | C | 0.4968 | 1 | -0.014 | 0.0024 | 8.20E-09 |
14 | rs17474406 | 5 | 123000000 | CEP120 | G | A | 0.01805 | 1 | -0.0492 | 0.0088 | 2.40E-08 |
15 | rs1946247 | 5 | 161000000 | GABRB2 | T | G | 0.1389 | 1 | -0.019 | 0.0035 | 4.90E-08 |
16 | rs11751591 | 6 | 33794215 | MLN | G | A | 0.1516 | 1 | 0.0214 | 0.0034 | 2.70E-10 |
17 | rs6907508 | 6 | 34592090 | C6orf106 | A | G | 0.1146 | 1 | -0.0217 | 0.0038 | 1.10E-08 |
18 | rs6926377 | 6 | 145000000 | UTRN | A | C | 0.294 | 1 | -0.0155 | 0.0027 | 7.90E-09 |
19 | rs10259354 | 7 | 3487414 | SDK1 | G | A | 0.2983 | 1 | 0.0147 | 0.0026 | 3.00E-08 |
20 | rs7798894 | 7 | 21552995 | SP4 | A | T | 0.2888 | 1 | 0.0153 | 0.0027 | 1.60E-08 |
21 | rs6966540 | 7 | 95727967 | DYNC1I1 | T | C | 0.3762 | 1 | -0.0139 | 0.0025 | 3.30E-08 |
22 | rs12537376 | 7 | 114000000 | FOXP2 | A | G | 0.3969 | 1 | 0.0151 | 0.0025 | 1.70E-09 |
23 | rs11786084 | 8 | 143000000 | AC138647.1 | G | A | 0.3328 | 1 | -0.0145 | 0.0026 | 2.30E-08 |
24 | rs10992729 | 9 | 96181075 | Y_RNA | C | T | 0.3344 | 1 | 0.0158 | 0.0026 | 1.10E-09 |
25 | rs6478241 | 9 | 119000000 | ASTN2 | A | G | 0.365 | 1 | 0.0149 | 0.0025 | 3.10E-09 |
26 | 9:140251458_G_A | 9 | 140000000 | EXD3 | G | A | 0.123 | 1 | -0.0277 | 0.0037 | 5.30E-14 |
27 | rs2183271 | 10 | 21957229 | MLLT10 | T | C | 0.3578 | 1 | -0.014 | 0.0025 | 3.10E-08 |
28 | rs11599236 | 10 | 106000000 | SORCS3 | T | C | 0.4058 | 1 | 0.0138 | 0.0025 | 3.30E-08 |
29 | rs12765185 | 10 | 135000000 | KNDC1 | T | A | 0.2669 | 1 | -0.0151 | 0.0027 | 3.90E-08 |
30 | rs61883178 | 11 | 16317779 | SOX6 | C | A | 0.1696 | 1 | -0.0208 | 0.0033 | 2.00E-10 |
31 | rs1443914 | 13 | 53917230 | AL450423.1 | T | C | 0.475 | 1 | 0.0162 | 0.0024 | 2.80E-11 |
32 | rs12435797 | 14 | 73797669 | NUMB | G | T | 0.1859 | 1 | -0.0173 | 0.0031 | 3.70E-08 |
33 | rs2006281 | 14 | 104000000 | CTD-2134A5.4 | C | T | 0.4981 | 1 | 0.0135 | 0.0024 | 3.40E-08 |
34 | rs2386584 | 15 | 91539572 | PRC1 | T | G | 0.3835 | 1 | -0.0166 | 0.0025 | 2.80E-11 |
35 | rs285026 | 16 | 77100089 | MON1B | G | T | 0.4297 | 1 | -0.0138 | 0.0025 | 1.90E-08 |
36 | rs11871043 | 17 | 43172849 | NMT1 | T | C | 0.4213 | 1 | 0.0149 | 0.0025 | 1.70E-09 |
37 | rs11079993 | 17 | 50301552 | snoZ178 | G | T | 0.3825 | 1 | -0.0173 | 0.0025 | 5.70E-12 |
38 | rs62098013 | 18 | 50863861 | DCC | G | A | 0.3631 | 1 | -0.0169 | 0.0026 | 4.00E-11 |
39 | rs2424248 | 20 | 19650324 | SLC24A3 | G | A | 0.1255 | 1 | 0.023 | 0.0037 | 3.70E-10 |