Table 2.
RLS genetic risk factors | Proposed functions in the nervous system | Predicted C. elegans orthologs* |
---|---|---|
MEIS1 | Neurogenesis | UNC-62 |
BTBD9 | Long-term memory potentiation, Fe homeostasis | HPO-9 |
PTPRD | Axonal guidance/myelination, neural development | PTP-3 |
MAP2K5 | Neurogenesis | MEK-2 |
TOX3 | Neural protection in CNS injury, neurogenesis | HMG-6 |
, the orthologs are predicted based on their amino acid sequence similarity, but have not been individually verified.