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Genetic risk factors of RLS.
| RLS genetic risk factors | Proposed functions in the nervous system | Predicted C. elegans orthologs* |
|---|---|---|
| MEIS1 | Neurogenesis | UNC-62 |
| BTBD9 | Long-term memory potentiation, Fe homeostasis | HPO-9 |
| PTPRD | Axonal guidance/myelination, neural development | PTP-3 |
| MAP2K5 | Neurogenesis | MEK-2 |
| TOX3 | Neural protection in CNS injury, neurogenesis | HMG-6 |
, the orthologs are predicted based on their amino acid sequence similarity, but have not been individually verified.
