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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Exp Neurol. 2019 May 8;318:157–164. doi: 10.1016/j.expneurol.2019.05.002

Table 1A.

CLFB-1134 Pharmacokinetic Properties in C57BL/6J Mice

IV Dose 10mg/kg PO Dose 30 mg/kg
*30% solutol in saline
PLASMA
AUC 5575 7854
T ½ (hr) 2.6 3.3
V2 (mL/kg) 6745 1255
CLZ (mL/hr/kg) 1793 2.0
%F 47
BRAIN
AUC 7286 7185
T ½ (hr) 1.4 3.3
V2 (mL/kg) 2858 765
CLZ (mL/hr/kg) 1372 2.0

CLFB-1134 displays a favorable pharmacokinetic profile in mice with high brain penetrance CLFB-1134’s concentration in plasma in brain following intravenous (IV) or oral (PO) dosing. AUC=area under curve, T ½ (hr) = half life time in hours. V2 = compartment volume.