Table 1C.

CLFB-1134 Chronic Dosing Pharmacokinetic Properties in Sprague-Dawley Rats.

7 Day Day	Male Plasma (ng/mL)	10 mg/kg Brain (ng/g)	B/P	20 mg /kg Plasma (ng/mL)	Brain (ng/g)	B/P
1	714	881	1.2	1496	1695	1.1
7	255	446	1.7	453	543	1.2
% of Day 1	35%	51%		30%	32%

7 Day Day	Female Plasma (ng/mL)	10 mg/kg Brain (ng/g)	B/P	20 mg /kg Plasma (ng/ mL)	Brain (ng /g)	B/P
1	240	494	2.0	1051	640	0.61
7	104	157	1.5	234	441	1.9
% of Day 1	43%	31%		22%	68%

35 Day Day	Male Plasma (ng/mL)	20** mg/kg Brain (ng/g)	B/P
1	1496	1695	1.2
35	292**	359**	1.2
% of Day 1	20%**	21%**