Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Strain, strain background (M. musculus)	C57B1/6	Jackson Laboratory	Cat. #000664	NA
Genetic reagent (M. musculus)	Tau KO (Mapt–/–)	Jackson Laboratory (Dawson et al., 2001)	Cat. #007251	Prof. Michael Vitek (Duke University Medical Center)
Antibody	Rabbit anti-Fyn	Cell Signalling Technologies	Cat. #4023	IF (1:500)
Antibody	Mouse anti-PSD-95	Merck Millipore	Cat. #MABN68	IF (1:500)
Antibody	Chicken anti MAP2	Merck Millipore	Cat. #AB15452	IF (1:500)
Recombinant DNA reagent	mCardinal-N1	Addgene	Cat. #54590
Recombinant DNA reagent	pEGFP-N1	Clontech/NovoPro	Cat. #V12021
Recombinant DNA reagent	Fyn-mEos2	This paper
Recombinant DNA reagent	Tau-GFP	PMID: 27378256		Prof. Jürgen Götz (Queensland Brain Institute, University of Queensland)
Recombinant DNA reagent	Tau-P301L-GFP	PMID: 27378256		Prof. Jürgen Götz (Queensland Brain Institute, University of Queensland)
Recombinant DNA reagent	ΔTau-GFP	Cummins et al., 2019		Prof. Jürgen Götz (Queensland Brain Institute, University of Queensland)
Chemical compound, drug	Phalloidin-Alexa Fluor 647	NEB	Cat. #8940S	IF (1:100)
Software, algorithm	Fiji-ImageJ	ImageJ (http://imagej.nih.gov/ij/)	RRID:SCR_003070	Version 2.0.0-rc-68/1.52e
Software, algorithm	Neurolucida	MBF Bioscience	RRID:SCR_001775
Software, algorithm	Huygens software	Scientific Volume Imaging	RRID:SCR_014237
Software, algorithm	Metamorph software	Molecular Devices (https://www.moleculardevices.com)	RRID:SCR_002368	Version 7.7.8
Software, algorithm	PALMTracer	http://www.iins.u-bordeaux.fr/team-sibarita-PALMTracer
Software, algorithm	SR-Tesseler	Levet et al., 2015 (http://www.iins.u-bordeaux.fr/team-sibarita-SR-Tesseler)
Software, algorithm	SharpViSu	Andronov et al., 2016 (https://github.com/andronovl/SharpViSu)
Software, algorithm	DC-MSS	Vega et al., 2018 (https://github.com/kjaqaman/DC-MSS)
Software, algorithm	Graphpad Prism	GraphPad Prism (https://graphpad.com)	RRID:SCR_015807	Version 7.0d