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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Neurochem Res. 2018 Apr 4;44(1):5–11. doi: 10.1007/s11064-018-2511-1

Figure 3. Dual-pathway proteolysis of APP by γ-secretase.

Figure 3.

Cleavage at the ε site occurs at one of 2 sites, resulting in Aβ49 and AICD50–99 or Aβ48 and AICD49–99. Subsequent carboxypeptidase trimming leads to two Aβ product lines: Aβ49→Aβ46→Aβ43→Aβ40 and Aβ48→Aβ45→Aβ42→Aβ38.