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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Trends Biochem Sci. 2019 Jan 2;44(4):300–311. doi: 10.1016/j.tibs.2018.12.002

Figure I. Structural Insights into RSK Activation.

Figure I.

(A) Schematic representation of RSK activation. The panel shows the two kinase domains (NTK and CTK), PDK1, and ERK binding SLiMs, and the phosphor switches regulated by the different kinases. (B) Structural model of the ERK-RSK complex. This panel shows the crystal structure of the ERK-CTK binary complex loosely attached to the NTK (dotted red line) and the structure of the inactive NTK. Phosphorylation of the hydrophobic motif(HM)(black dot) in the linker is mediated by the CTK. The Ctail of the CTK is indicated by the red ribbon. Abbreviations: AL, activation loop; CTK, C-terminal kinase; ERK, extracellular signal-regulated kinase; HM, hydrophobic motif; IDR, intrinsically disordered region; NTK, N-terminal kinase; RSK, ribosomal S6 protein kinase.