Extended Data Table 1.

Mutations in the HIV-1 L mutant and its derivatives

Virus	Mutations	CG dinucleotides added	CG dinucleotides total	GC dinucleotides total
WT	none	0	2	18
L	145 synonymous mutations	37	39	25
LCG	37 mutations (subset of L mutations that generate new CG dinucleotides)	37	39	27
LOTH	108 mutations (subset of L mutations that do not generate new CG dinucleotides)	0	2	19
LCG-HI	41 mutations	41	43	18
LGC-HI	9 mutations	0	2	27