Table 1:

Condition	Effects on AElIs	Effects on Surfactant Homeostasis	Phenotypic Changes in Alveolar Macrophages	Functional Changes of Alveolar Macrophages
Chronic Alcohol Use Disorder	↑Lipid Synthesis35 ↓junctional proteins46,55 ↓GM-CSF receptors	↑Total and free cholesterol, ↑cholesteryl ester in lavage, PL, PC, and PG47	↑ M2 phenotype5,35,37 ↑ “foamy” cytopathology35	↓Phagocytosis34,37,39,45 ↓Chemotaxis and Cytokine production34,37,39,45 ↓ GM-CSF receptor,
Pulmonary Alveolar Proteinosis (PAP)	Normal lipid synthesis	↑Free and esterified cholesterol51	↑ “foamy” cytopathology21,51	↓Phagocytosis56 ↓Chemotaxis, and bacterial killing33 ↓Cytokine production ↓Surfactant clearance ↓ GM-CSF signaling
GM-CSF KO mice	Normal lipid synthesis	↑Surfactant proteins in alveolar space15,53 ↑Sat PC57,58	↑ Mixed M1/M2 phenotype ↑ “foamy” cytopathology21	↓Phagocytosis17,41,59 ↓Bacterial Killing41,59 ↓Cytokine production17,18 ↓Surfactant clearance14,18,39 ↓ GM-CSF signaling