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. Author manuscript; available in PMC: 2019 Jun 25.
Published in final edited form as: Biochem Biophys Res Commun. 2011 Oct 22;415(3):445–449. doi: 10.1016/j.bbrc.2011.10.089

Fig. 2. Deletion of HIF-1α gene evokes glucose intolerance in mice treated with HFSD.

Fig. 2

(A) Oral glucose tolerance test. Mice were administered orally glucose at a dose of 2 mg/g body weight after being treated with HFSD for either 5 (left) or 20 (right) weeks. Values are mean ± SEM. for at least 6 different experiments. *P < 0.05 compared to control mice. (B) Quantitative PCR analysis of GK in liver of 5 weeks-HFSD-treated mice. Values are expressed as mean ± SEM. *P < 0.05 compared to control mice for at least 6 different experiments. (C) Western blot analysis of GK in liver from mice treated with HFSD for 5 weeks. (D) Histochemical analysis of hepatic GK in control and H-HIFKO mice exposed to 5 weeks-HFSD. (E) Uptake of 2-deoxy-glucose by liver treated with HFSD for 5 weeks. Values are mean ± SEM. for at least 6 different experiments. P < 0.05 compared to control mice.