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. 2019 Feb 22;13(7):1647–1658. doi: 10.1038/s41396-019-0375-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Spearman correlations between variance-stabilised relative OTU abundance and metabolite ions. Only correlations ≥ 0.5 are presented (positive correlations: blue; negative correlations: red). OTUs that are Bx-stimulated (enriched in the WT relative to the bx mutants) form one cluster (1). Bx-repressed OTUs (were enriched in bx mutants relative to WT) form three clusters (2–4). Pie charts show the distribution of putative metabolites between various metabolite pathways/classes for each cluster. The top eight correlations from each cluster are shown in Fig. S13