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. Author manuscript; available in PMC: 2019 Jun 25.
Published in final edited form as: Mol Microbiol. 2017 Feb 6;104(1):92–104. doi: 10.1111/mmi.13614

Fig. 2.

Fig. 2

A. Treatment of NCTC11168 with the DNA gyrase inhibitor novobiocin results in dose dependent DNA relaxation as observed in mid log bacteria. Treatment of NCTC11168 overnight cultures with sub-inhibitory concentrations of novobiocin results in a dose dependent increase in bacterial invasion of the HCT-8 (B) and Caco2 (C) cell lines after 5 h. * denotes a P value <0.05 compared to the untreated strain. (D) Immunofluorescence microscopy confirms a higher rate of HCT-8 cell interaction following culture of NCTC11168 in the presence of novobiocin.