LC-MS of bacterial supernatants grown in the absence and presence of novobiocin.
A. Numbers of proteins found within the supernatant of strain NCTC11168 grown in the absence and presence of novobiocin reveals the extent of increased protein secretion following DNA relaxation.
B. Many of the proteins found within the supernatant of NCTC11168 following DNA relaxation are also secreted by the less negatively supercoiled strain 81-176 in the absence of novobiovin.