Figure 4.

Schematic representation showing stimulation of β‐adrenoceptors (βAR) leading to activation of the Hippo signalling pathway through phosphorylation and inactivation of the transcription co‐regulator of YAP with resultant disinhibition of expression of Gal‐3 gene (Lgals3). Ep: epigenetic factors; Lats1/2: large tumour suppressor homolog1/2; Mst1/2: mammalian sterile‐20 like kinase1/2; P: phosphorylation; TAZ: transcriptional coactivator with PDZ‐binding motif; TF: transcription factors; YAP: yes‐activated protein. Possible therapeutic targets for drug intervention are indicated as inhibition (⊣) or activation (→)