Table 2.
Effects of pretreatment on relaxation responses of isolated rat bladder to β‐adrenocpetor (AR) agonists
| Relaxing agonist | Isoprenaline | Fenoterol | CL316,243 | Mirabegron | ||||
|---|---|---|---|---|---|---|---|---|
| Pretreatment | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax |
| Vehicle | 7.34 ± 0.06 | 49 ± 5 | 6.99 ± 0.23 | 42 ± 3 | 8.45 ± 0.24 | 30 ± 5 | 5.55 ± 0.17 | 45 ± 4 |
| Isoprenaline | 7.01 ± 0.09 | 26 ± 4* | 8.39 ± 0.33* | 19 ± 2* | 8.65 ± 0.35 | 12 ± 3* | 5.52 ± 0.49 | 40 ± 4 |
| Fenoterol | 7.46 ± 0.16 | 24 ± 5* | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. |
| CL316,243 | 7.36 ± 0.02 | 38 ± 3 | 6.63 ± 0.17 | 33 ± 4 | 8.82 ± 0.25 | 20 ± 2 | n.d. | n.d. |
| Mirabegron | 7.08 ± 0.13 | 35 ± 4 | 6.63 ± 0.10 | 34 ± 3 | n.d. | n.d. | 4.84 ± 0.13 | 45 ± 4 |
Note: β‐adrenoceptor agonist potency (pEC50) is given in –log molar units and maximum relaxation (Emax) in %. Data are means ± SEM of 3–8 experiments.
*
P < 0.05 versus vehicle pretreatment in one‐way ANOVA followed by Dunnett's multiple comparison tests; n.d.: not determined. Reproduced with permission from Michel (2014).