Figure 1.

Schematic drawing and trace recording of a typical experiment showing the systolic arterial pressure (SAP) of an anaesthetized control rat. Bradykinin and angiotensin II intravenously administered before and after treatment with losartan (15 mg·kg⁻¹, i.v.). The protocol and experiment showed here were performed in anaesthetized rats at 24 hr after intraperitoneal administration of LPS (1 mg·kg⁻¹) or PBS (1 ml·kg⁻¹). The box below the figure presents the antagonists and inhibitors used in these experiments. For additional details about the protocols, see Section 2