Figure 3.

Activation of bradykinin B₂ receptors accounts for the pressor effect of bradykinin in endotoxemic female rats. Secondary pressor responses to intravenous bradykinin and des‐Arg⁹‐bradykinin (DABK) and influence of the selective inhibition of B2 receptors by Hoe‐140 (27 mg·kg⁻¹, s.c.) or B₁ receptors by des‐Arg⁹‐[Leu⁸]‐bradykinin (DALBK; 87 mg·kg⁻¹, i.v.) on the peak (a) and AUC (c) of the pressor effect of bradykinin in the control (PBS treated) and endotoxemic (LPS treated) rats. (b) Effects of Hoe‐140 and DALBK in the systolic arterial pressure of the control and endotoxemic animals. (d) Induction of paw oedema by the intraplantar injection of DABK (100 nmol) in the control and LPS groups. These experiments were performed in anaesthetized female rats at 24 hr after intraperitoneal administration of LPS (1 mg·kg⁻¹) or PBS (1 ml·kg⁻¹, control group). The results are presented as the mean ± SEM or the dot plot of values obtained from six animals per group. *P < .05, significantly different from the control group; ^# P < .05, significantly different from the respective group before administration of Hoe‐140 or DALBK; Student's t test (b) or two‐way ANOVA followed by Bonferroni's post‐test (a, c, d)