Figure 6.
Involvement of the Rho‐A/Rho‐kinase (ROCK) pathway in the pressor effect of bradykinin in endotoxemic rats. Reduction of BP after intravenous administration of indomethacin (a) or Y‐27632 (c). Lack of influence of indomethacin (b) and inhibitory effect of Y‐27632 (d) against the pressor effect of bradykinin endotoxemic rats. These experiments were performed in anaesthetized female rats 24 hr after intraperitoneal administration of LPS (1 mg·kg−1) or PBS (1 ml·kg−1, control group). The results are presented as a dot plot or as the mean ± SEM of values obtained from six animals per group. *P < .05, significantly different from the control group; # P < .05, significantly different from the respective group before administration of Y‐27632; Student's t test (a, c) or two‐way ANOVA followed by Bonferroni's post‐test (b, d)