Figure 9.
The potentiation of the pressor effect of angiotensin II is prevented by the bradykinin B2 receptor antagonist Hoe‐140. Trace recordings of experiments showing the pressor effects of angiotensin II before and after administration of Hoe‐140 in the control (a) and LPS‐treated (b) rats. Treatment with Hoe‐140 that reduced the peak (c) and the AUC (d) of the pressor effect of angiotensin II did not affect the hypertensive action of phenylephrine (e). These experiments were performed in anaesthetized female rats 24 hr after intraperitoneal administration of LPS (1 mg·kg−1) or PBS (1 ml·kg−1, control group). The results are presented as the mean ± SEM of values obtained from six animals per group. Statistical analyses were performed using *P < .05, significantly different from the control group; # P < .05, significantly different from the respective group before administration of Hoe‐140; two‐way ANOVA followed by Bonferroni's post‐test