Table 2.

In vivo and in vitro studies on desensitisation of β₃‐adrenoceptor function

Tissue	Species	Response	Intervention	Outcome	Reference
In vivo treatments
White adipocytes	Hamster	Lipolysis	Noradrenaline 5 μg·min−1·kg−1 infusion, 6 days	No change	Carpene et al., 1993
White adipocytes	Rat	Oxygen consumption	FR 149,175, 0.1–3.2 mg·kg−1 twice daily orally, 2 weeks	No change	Hatakeyama, Sakata, Takakura, Manda, & Mutoh, 2004
Ileum	Mouse	Relaxation	CL 316,243, 1 mg·kg−1 injection, 1 hr	No change	Hutchinson, Evans, & Summers, 2000
			CL 316,243, 1 mg·kg−1 injection, 4 or 24 hr	Reduced
Pulmonary artery	Rat	Relaxation	Isoprenaline 0.3 mg·kg−1·day−1 injection, 7 days	No change	Davel, Victorio, Delbin, Fukuda, & Rossoni, 2015
In vitro treatments
Myometrium	Human	Relaxation	SR 59,119, 10 μM, 5 or 15 hr	No change	Rouget et al., 2004
Urinary bladder	Rat	Relaxation	Isoprenaline, CL 316,243, mirabegron 10 μM each, 6 hr	No change	Michel, 2014

Note: For details, see Section 2.