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. 2019 Jun 25;9:9238. doi: 10.1038/s41598-019-45684-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Organ scale transplantation of PSC-CMs into a personalized 3D heart model of ischemic cardiomyopathy. (a) Any combination of delivery locations and cell dosages can be simulated in an individualized, 3D whole heart model; PSC-CMs can be distributed across multiple sites around the scar, grey zone, and non-infarcted tissue. (b) In the context of PSC-CM cell sheets, cell dosage can be adjusted by altering sheet size or thickness. (c) Myofibril discontinuity arising from the misorientation of cell sheets with aligned PSC-CMs can also be simulated.