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. 2019 Jun 25;9:9238. doi: 10.1038/s41598-019-45684-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transplantation of PSC-CM cell sheets results in reentrant VT in a 3D personalized heart model of ischemic cardiomyopathy. (a) Cell sheet transplantation (radius, r = 3.2 cm) was simulated at two sites: the lateral LV (middle) and posterior, superior LV (right). Five different cell sheet conditions (anisotropic [0°, ±45°, 90°] isotropic) were simulated (left). (b,c) Induced reentrant arrhythmias in the treated post-MI heart obtained following pacing from the site indicated by the star. Geometric models are presented together with electrical activation isochronal maps. Colors indicate time sequence of activation (ms). White arrows represent the direction of propagation of reentrant arrhythmias. (b) Reentrant VT morphology following cell sheet transplantation onto the lateral LV epicardium. (c) Reentrant VT morphologies following cell sheet transplantation onto the posterior, superior LV epicardium.