Table 1.
Local maxima of the change of the fMRI BOLD response in the VPA400 and VPA600 groups compared to the VEH control group.
| x | y | z | % Signal change | Z-score | Region | |
|---|---|---|---|---|---|---|
| VPA400 > VEHICLE | 3.1 | −0.4 | −1.2 | 0.42 | 6.89 | S1FL primary somatosensory cortex forelimb |
| −1.5 | 3.2 | −5.2 | 0.40 | 7.65 | VO ventral orbital cortex | |
| −5.1 | −3.0 | −2.8 | 0.31 | 4.97 | S1BF primary somatosensory cortex barrel field | |
| 2.7 | 3.4 | −4.4 | 0.29 | 6.68 | LO lateral orbital cortex | |
| 1.1 | 0.6 | −2.2 | 0.28 | 5.81 | Cg1 cingular cortex | |
| −7.7 | −4.0 | −6.8 | 0.20 | 6.83 | Ect ectorhinal cortex | |
| 2.1 | 4.8 | −2.2 | 0.17 | 5.98 | FrA frontal association cortex | |
| −4.5 | 0.8 | −8.6 | 0.16 | 4.80 | Pir piriform cortex | |
| 2.9 | 2.8 | −6.0 | 0.16 | 4.49 | VO ventral orbital cortex | |
| 2.3 | 1.0 | −6.8 | 0.16 | 5.22 | CPu striatum | |
| −2.7 | −8.6 | −7.6 | 0.15 | 4.75 | brainstem (lateral lemniscus) | |
| −7.3 | −3.4 | −4.4 | 0.15 | 6.09 | Au1 primary auditory cortex | |
| 2.5 | −8.2 | −7.6 | 0.14 | 4.64 | brainstem (lateral lemniscus) | |
| −7.7 | −5.0 | −7.4 | 0.12 | 4.41 | Ect ectorhinal cortex | |
| VPA600 > VEHICLE | 2.5 | −0.4 | −1.2 | 0.51 | 6.91 | S1HL primary somatosensory cortex hindlimb |
| 1.9 | 2.0 | −2.4 | 0.35 | 7.47 | M1 primary motor cortex | |
| 3.3 | 2.4 | −1.6 | 0.30 | 4.47 | M1 primary motor cortex | |
| 5.3 | −2.8 | −2.8 | 0.30 | 4.33 | S1BF primary somatosensory cortex barrel field | |
| 3.1 | −0.6 | −2.0 | 0.29 | 4.90 | S1FL primary somatosensory cortex forelimb | |
| −0.9 | −5.2 | −6.0 | 0.23 | 4.31 | thalamus | |
| −1.5 | 3.0 | −6.2 | 0.22 | 4.71 | VO ventral orbital cortex | |
| 2.1 | 4.6 | −2.2 | 0.15 | 4.44 | FrA frontal association cortex | |
| −7.3 | −3.4 | −4.4 | 0.14 | 4.30 | Au1 primary auditory cortex | |
| 4.5 | 3.0 | −5.8 | 0.06 | 5.01 | AIV agranular insular cortex | |
| VPA400 > VPA600 | −5.1 | −3.0 | −2.8 | 0.37 | 5.55 | S1BF primary somatosensory cortex barrel field |
| 1.1 | 4.4 | −4.4 | 0.36 | 8.50 | VO ventral orbital cortex | |
| −1.3 | 5.0 | −2.4 | 0.24 | 4.78 | FrA frontal association cortex | |
| 5.1 | 1.4 | −2.8 | 0.22 | 4.98 | S1J primary somatosensory cortex jaw | |
| −7.7 | −4.4 | −6.8 | 0.20 | 6.17 | Ect ectorhinal cortex | |
| 3.7 | −1.0 | −5.2 | 0.19 | 4.58 | CPu striatum | |
| −2.9 | −8.8 | −7.4 | 0.16 | 4.90 | brainstem (lateral lemniscus) | |
| −0.5 | −13.4 | −5.4 | 0.14 | 5.05 | lobule VIII cerebellum | |
| −2.7 | −11 | −7.4 | 0.14 | 4.48 | brainstem (lateral lemniscus) | |
| −2.3 | −14.0 | −4.8 | 0.13 | 5.06 | lobule VIII cerebellum | |
| −2.5 | 5.4 | −2.6 | 0.12 | 4.46 | FrA frontal association cortex | |
| 2.3 | −13.0 | −6.2 | 0.11 | 4.30 | crus II cerebellum | |
| 4.7 | −13.4 | −6.2 | 0.10 | 4.50 | crus II cerebellum | |
| 3.7 | 3.8 | −6.0 | 0.09 | 4.58 | LO lateral orbital cortex |
Only local maxima above the FWER P > 0.05 threshold (|Z| > 4.29) are shown. The minimum peak distance is set to 3 mm. Peaks are listed by effect size (% BOLD signal change) in decreasing order. Coordinates are given relative to bregma, according to the atlas of Paxinos and Watson (x: medial-lateral, y: anterior-posterior, z: dorsal-ventral).