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. 2019 Jun 25;9:9224. doi: 10.1038/s41598-019-45661-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The network analysis for differential candidate gene in hypoxia condition for carcinogenesis. The high-dose UV radiation can lead to DNA damage and tumorigenesis in high-altitude condition; thus, gene networks analyses of key genes involved in the high-altitude adaptation could provide new information about carcinogenesis. A total of 27 candidate genes was identified for differential variants in males and females in this investigation (Tables 7 and 8). Chicken Ensembl gene identifications were converted into human orthologs in order to construct an informative network and finally, results showed that seven candidate genes were enriched in carcinogenesis network and had a regulatory role. Specifically, BMX and LRP6 induce the carcinogenesis and HSPA14, and DCLRE1A inhibits that.