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. 2019 Jun 25;9:9224. doi: 10.1038/s41598-019-45661-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The cellular location of the key proteins in the regulation of carcinogenesis. This figure shows the cellular location of the key proteins in three parts of the cell (Membrane, Nucleus and Cytoplasm). LRP6 is known as receptor, thus cellular location of this protein is shown in the membrane. Similarly, other proteins including DCLRE1A contribute in the DNA repair process. Consequently, it is illustrated in nucleus. These results can be useful for better understanding of the diseases creation process and the selection of appropriate drug design methods, based on cellular locations of key proteins in carcinogenesis.