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. 2019 Jun 25;9:9259. doi: 10.1038/s41598-019-45710-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spearman’s rank tests between SNR improvement and experimental parameters. The SNR improvement derived from AOC was correlated against (a) PUFA content for breast tumour specimens, (b) PUFA content for healthy volunteers, (c) voxel volume for breast tumour specimens, and (d) water/fat ratio for breast tumour specimens. Each dot represents an individual measurement. Spearman’s rho and p-value are displayed. Correlation against voxel volume for healthy volunteers was not conducted since the voxel remained constant across the entire cohort. Moreover, since the voxel was positioned in the adipose tissue, water signal was not detected. Therefore, correlation between SNR improvement and water/fat ratio was not conducted for healthy volunteers. AOC = adaptively optimised combination, PUFA = polyunsaturated fatty acids, SNR = signal to noise ratio.