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. 2019 Jun 25;9:9276. doi: 10.1038/s41598-019-45635-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depolarizing GABA signaling in hippocampal CA3 pyramidal neurons of Mecp2^−/y newborn and P15 mice. (a) Average values of DF_GABA at P0 in wt and Mecp2^−/y neurons. (b) Average values of DF_GABA at P0 in control condition and in the presence of bumetanide (10 µM) in Mecp2^−/y neurons. (c) Representative I/V curves of hippocampal CA3 pyramidal cells at P0 using cell-attached recordings of single GABA_AR channels for the estimation of the DF_GABA in a representative Mecp2^−/y and Mecp2^−/y + bumetanide acute neuron. Inset shows single-channel GABA_AR-mediated currents recorded at imposed voltages (−Vp, mV) in a Mecp2^−/y P0 pyramidal cell. Dashed lines show the average values of channel openings. Note the two levels of openings at 40 and 60 mV. (d) Average values of DF_GABA in wt and Mecp2^−/y neurons at P15. Data are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001. (a,b,d) Significance was determined by two-tailed t-test. (see Supplementary Table 1 for detailed statistics).