Table 5.
Dual substrate incubations in porcine hepatic microsomes.
| TB | CZ | CM | PH | MDZ | DXM | |
|---|---|---|---|---|---|---|
| TB | — | 0.97 (0.026) | 0.92 (0.021) | 0.88 (0.024) | 1.01 (0.031) | 0.97 (0.043) |
| CZ | 0.87 (0.014) | — | 0.57 (0.012) | 0.59 (0.006) | 0.98 (0.053) | 0.93 (0.073) |
| CM | 0.89 (0.043) | 0.86 (0.007) | — | 0.83 (0.020) | 0.92 (0.038) | 0.99 (0.072) |
| PH | 0.88 (0.033) | 0.73 (0.041) | 0.55 (0.027) | — | 0.93 (0.032 | 0.95 (0.106) |
| MDZ | 0.55 (0.041) | 1.23 (0.019) | 0.62 (0.027) | 0.71 (0.011) | — | 0.50 (0.034) |
| DXM | 0.82 (0.153) | 0.95 (0.050) | 0.86 (0.106) | 0.82 (0.082) | 0.84 (0.115) | — |
Results are presented as the ratio of the reaction rate of dual substrates versus single substrate incubations. The means are presented of 3 replicate measurements (and standard deviation).
TB, tolbutamide; CZ, chlorzoxazone; CM, coumarin; PH, phenacetin; MDZ, midazolam; DXM, dextromethorphan.