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. 2019 May 21;27(1):433–449. doi: 10.1007/s40199-019-00267-2

Table 2.

List of phenolic acids

Phenolic acid name Concentration Cell line Mechanisms Reference

Tatariside B

Tatariside C

Tatariside D

18.3 μg/mL

6.44 μg/mL

2.83 μg/mL

A549 Inhibition of proliferation of cell line [63]
4-ACGC

37.73 μg/mL

50.6 μg/mL

62.0 μg/mL

A549

NCI-H1299

HCC827

Upregulation of caspase-3 & 9, Bad, and Bax

down-regulation of Bcl-2

[64]
p-Coumaric acid 50–100 μM H1993 Suppression of cell viability [61]
50–1000 μM A549 Decreased proliferation, superoxide anion production, cell adhesion, and cell migration [66]
Salicylic acid 6.0 mM A549 Proapoptotic, antiproliferative, and cytotoxic effects [68]
Gallic acid

10–50 μM

100–200 μM

Calu 6

A549

Depletion of glutathione and increasing ROS levels [70]
50 μM H1975 Inhibition of Src-mediated STAT3 phosphorylation, leading to downregulation of STAT3 target genes (Bcl2 and cyclin D) causing apoptosis and cell cycle arrest [71]
5 μM H1993 Inhibition of Src-mediated STAT3 phosphorylation, leading to downregulation of STAT3 target genes (Bcl2 and cyclin D) causing apoptosis and cell cycle arrest [61]
Caffeic acid 50–1000 μM A549 Decreased proliferation, superoxide anion production, cell adhesion, and cell migration [66]
Ferulic acid 50–1000 μM A549 Decreased proliferation, superoxide anion production, cell adhesion, and cell migration [66]