Table 3.

List of studies where curcumin showed anticancer activity against various lung cancer cell lines

Diphenylalkaloid	Concentration	Cell line	Mechanisms	Reference
Curcumin	30 μM	A-549	Caspase-3 induced apoptosis. TP53-independent apoptosis	[81]
	40–50, 160 μM	A549 H1299	TP53-independent induction of apoptosis	[82]
	10–20 μM	A549	MMP 2&9 mediated inhibition of invasion and metastasis	[83]
	30 μM	NCI-H460	Caspase-3 & 8 induced apoptosis	[84]
	5–20 μmol/L	CL1–5	Upregulation of tumour suppressor HLJ1	[85]
	50 μM	PC-9	Apoptosis via upregulation of GADD 45 and 153	[86]
	15 μmol/L	SK-MES-1	Upregulation and downregulation of genes	[87]