Table 5.

List of phenolic compounds and the polymeric nanoparticles used in their delivery

Nanoparticulate system	Phenolic compound	Effect	Reference
PLGA PLGA-PEG	Curcumin	PLGA and PLGA-PEG nanoparticles: - increased the peak concentration of curcumin by 2.9- and 7.4-fold - increased the half-life of the curcumin from 1 h to 4 h (PLGA) and 6 h (PLGA-PEG) - enhanced the oral bioavailability of curcumin by 15.6- and 55.4-fold, respectively	[123]
Chitosan Gelatin Hyaluronan	Curcumin	Polymeric chitosan, gelatin, and hyaluronan nanoparticles: - All showed enhanced apoptotic effects of 45, 40 and 32%, respectively, as opposed to pure curcumin (>20%) on A549 cells	[124]
Chitosan	naringenin	naringenin encapsulated chitosan nanoparticles (NAR/CS NPs): - caused a statistically significant dose-dependent decrease in cell viability in A549 cells as compared with free naringenin, without affecting the normal 3T3 cells	[126]
Gelatin	Resveratrol	Resveratrol encapsulated in gelatin nanoparticles: - induced cell death in human lung cancer cells NCI-H460 by changing the expression of TP53, p21, caspase-3, Bax, Bcl-2 and NF-κB	[119]
Gelatin	Resveratrol	Resveratrol encapsulated gelatin nanoparticles (R-GNPs): - improved cellular uptake and superior bioavailability, decreasing cell viability, mitochondrial membrane potential and increasing cytotoxicity, DNA damage and intracellular ROS levels as compared to free resveratrol in NCI-H460 cells	[127]
PLGA	EGCG	The EGCG-encapsulated PLGA nanoparticles: - decreased IC50 of EGCG from 60 μM (free EGCG) to 9 μM (encapsulated-EGCG) - enhanced the sensitivity of the A549 cells to cisplatin by reducing the dose of cisplatin required by up to 20-fold	[128]