Table 3.

The side-effects of the drugs reported in the articles of this systematic review

Drug	Adverse effects	Ref	Drug	Adverse effects	Ref
Methadone	Shallow breathing Bradycardia Oxygen desaturation Lethargy Poor feeding Hypothermia Emesis	[6]	Buprenorphine	Anemia Skin condition Gastro-intestinal condition Cough Tachycardia Umbilical granuloma	[7]
				CMV infection* Aminoaciduria* Clavicle fracture* Elevated transaminases *	[11]
Morphine	Shallow breathing Bradycardia Oxygen desaturation Lethargy Poor feeding Hypothermia Emesis	[6]
				mild fungal paronychia *	[11] [12]
			Phenobarbital	poor feeding mild respiratory depression	[10]
			Clonidine/DTO	–
			Opium solution	–
			DTO	–
	Skin condition Gastro-intestinal condition Respiratory infection Urinary tract infection Oral thrush* conjunctivitis* reflux*	[7]

*probably unrelated in to intervention; Ref, Reference number; CMV, Cytomegalovirus; DTO, Tincture of opium