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. 2019 Jun 19;10:585. doi: 10.3389/fgene.2019.00585

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Copyright © 2019 Chen, Feng, Li, Jiang, Bei, Zhang, Han, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Representative immunoblot of pedunculoside (10 μM) restoring LATS2 levels that were down-regulated by miR-31-5p overexpression. (B) Representative immunofluorescent staining results of pedunculoside (10 μM) restoring the YAP/TAZ level after miR-31-5p overexpression. (C) RT-qPCR results of pedunculoside (10 μM) decreasing CTGF, AREG, and CYR61 levels that were increased by transfection of miR-31 precursor. Values are means ± S.E.M. from three separate experiments. ^∗P < 0.05 compared with the scramble group, and ^#P < 0.05 compared with the Pre-miR-31 group. (D) Immunofluorescent staining results of pedunculoside (10 μM) restoring the APC protein level. (E) Representative immunoblot of pedunculoside (10 μM) restoring the APC protein level.