Table 6.
Comparison of clinicopathological characteristics between incidental and overt PTMC.
| Characteristic | Incidental PTMC | Overt PTMC | P-value |
|---|---|---|---|
| n = 90 (25.5%) | n = 263 (74.5%) | ||
| Sex | |||
| Male | 18 (20.0%) | 71 (27.0%) | 0.187 |
| Female | 72 (80.0%) | 192 (73.0%) | |
| Age (Y) | |||
| ≥45 | 46 (51.1%) | 135 (51.3%) | 0.971 |
| <45 | 44 (48.9%) | 128 (48.7%) | |
| Tumor size (mm) | |||
| ≤ 5 | 65 (72.2%) | 112 (42.6%) | <0.001 |
| >5 | 25 (27.8%) | 151 (57.4%) | |
| BRAF mutation* | |||
| Absence | 0 (0.0%) | 5 (12.8%) | – |
| Presence | 0 (0.0%) | 34 (87.2%) | |
| Multifocality | |||
| Absence | 64 (71.1%) | 191 (72.6%) | 0.782 |
| Presence | 26 (28.9%) | 72 (27.4%) | |
| ETE | |||
| Absence | 79 (87.8%) | 236 (89.7%) | 0.605 |
| Presence | 11 (12.2%) | 27 (10.3%) | |
| Vascular invasion | |||
| Absence | 87 (96.7%) | 257 (97.7%) | 0.874 |
| Presence | 3 (3.3%) | 6 (2.3%) | |
| Surgery | |||
| Lobectomy+CND | 0 (0.0%) | 78 (29.7%) | <0.001 |
| TT+CND | 0 (0.0%) | 170 (64.6%) | |
| TT+CND+LND | 0 (0.0%) | 15 (5.7%) | |
| Lobectomy or partial thyroidectomy | 90 (100.0%) | 0 (0.0%) | |
| Recurrence** | |||
| Overall | 11 (12.2%) | 10 (3.8%) | 0.004 |
| LNs | 9 (10.0%) | 7 (2.7%) | 0.009 |
| Thyroid bed | 5 (5.6%) | 3 (1.1%) | 0.044 |
| Lung | 0 (0.0%) | 1 (0.3%) | 0.443 |
PTMC papillary thyroid microcarcinoma; Y, year; ETE, extrathyroidal extension; TT, total thyroidectomy; CND, central neck dissection; LND, lateral neck dissection; LN, lymph node.
*
BRAF mutation analysis was started in 2017 and it was performed in 39 patients with PTC.
**
More than one recurrence occurred in some patients. The bold values mean the P <0.05.