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. 2019 Jun 19;10:555. doi: 10.3389/fgene.2019.00555

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Copyright © 2019 Brugger, Kraemer, Qi, Bomar, Oppliger and Hilty.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Beta-diversity analyses of samples of children with AOM suggest a more personalized bacterial microbiota with age. Illustrated are (A) Weighted (Ružička) and (C) unweighted (Jaccard) distances in microbiota composition, reduced in a 2D-space by using NMDS, 95% confidence ellipse for the group centroid shown. In addition, shown are the beta-dispersion based on (B) Ružička and (D) Jaccard dissimilarity indices in each sample type. The boxplots represent median (midline), interquartile ranges (shaded boxes), and ranges (whiskers). Data is shown according to the age (years) of the children with AOM.