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. 2019 Jun 19;10:602. doi: 10.3389/fgene.2019.00602

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Copyright © 2019 Collas, Liyakat Ali, Brunet and Germier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of TAD cliques with the nuclear periphery. (A) Browser view showing de novo LADs appearing in pre-existing TAD cliques in a B compartment on day 3 of adipose differentiation. Sequence data can be accessed at NCBI GEO GSE109924 and GSE60237. (B) Radial positioning of TAD cliques in the nucleus: model views. Top, differential preferred radial position of a small (pink) and a large (red) TAD clique. Bottom, differentiation repositions a TAD clique toward the nuclear periphery; orange arrow symbolizes differentiation.