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. 2019 Jun 19;9:549. doi: 10.3389/fonc.2019.00549

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Copyright © 2019 Biau, Chautard, Berthault, de Koning, Court, Pereira, Verrelle and Dutreix.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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_⋎H2AX induction in gliomas cells after Dbait treatment. (A) _⋎H2AX induction in human gliomas cell lines after Dbait treatment. The nine glioma cell lines were untreated (NT), irradiated (IR, 10Gy), treated with Dbait (5h) or treated with Dbait and irradiated. One hour after treatment completion, total proteins were electrophoresed followed by immunobloting. The blots were analyzed using the Odyssey Infrared Imaging System (LI-COR Biosciences) and Odyssey software. The induction of _⋎H2AX (_⋎H2AX on H2AX ratio) is presented. Mann-Whitney test was performed (*p < 0.05). (B) MRI of a boxer dog with a spontaneously brain tumor. (C) Activation of DNA damage response in dog glioblastoma. Dissociated cells of dog glioblastoma were untreated (NT), irradiated or treated with Dbait (5 h). Cells were fixed and permeabilized after treatment before the use of anti- _⋎H2AX, anti-HSP90 antibodies and DAPI.