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. 2019 Jun 19;9:549. doi: 10.3389/fonc.2019.00549

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Copyright © 2019 Biau, Chautard, Berthault, de Koning, Court, Pereira, Verrelle and Dutreix.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Markers involved in Dbait treatment resistance. We analyzed a total of 88 proteic markers (see Table S1) to explore tyrosine kinase signaling, SAPK/JNK signaling, stress signaling, DNA repair, PI3K pathway, apoptosis, cell cycle, adhesion/cytoskeleton, MAPK/ERK signaling and NFκB signaling. Data obtained for 11 models (without any treatment) were analyzed with 6 replicates for each xenograft models to identify makers that can predict resistance to Dbait treatment. A Mann-Whitney test was performed (p < 0.05) between the two groups of models (sensitive and resistant to Dbait treatment).