Scheme 1.

Construction of Chiral Homoallylic Amines through Addition of Allylboronates to Ketimines

(A) Examples of biologically active homoallylamines.

(B) Cu-catalyzed addition of allylboronates to ketimines.

(C) Rh- or Co-catalyzed addition of allylboronates to ketimines.

(D) Cu-catalyzed three-component reaction of N–H ketimines.

(E) Addition of chiral allylboronates to ketimine.

(F) Addition of allylboronates to ketimines controlled by chiral reagent.

(G) Bi-catalyzed addition of allylboronates to ketimines.