Table 5.

Associations between changes in echocardiography measures early after doxorubicin chemotherapy (T₁) and changes in shortening fraction 1–2 years post chemotherapy (T₂)

Echocardiographic measure	Change in SF 1–2 years post-therapy (T2), %*	P†
Shortening fraction (%)	0.1 (−0.2 to 0.4)	0.52
LVIDD (cm/BSA0.45)	−0.8 (−5.0 to 3.4)	0.71
LVIDS (cm/BSA0.45)	−1.0 (−6.0 to 4.1)	0.70
Posterior wall thickness (mm/BSA0.4)	−1.6 (−3.2 to 0.0)	0.054
LV mass (10 g/BSA1.25)	−1.1 (−2.0 to −0.1)	0.025
Relative wall thickness (0.01 units)	−0.2 (−0.5 to 0.1)	0.22
Circumferential strain (%)†	−0.5 (−0.8 to −0.1)	0.010
Radial strain (%)	0.1 (0.0 to 0.2)	0.025
Meridional ESS (10*103 dynes/cm2)	−0.1 (−0.8 to 0.5)	0.68
Circumferential ESS (10*103 dynes/cm2)	−0.1 (−0.7 to 0.5)	0.85

*Percent change in SF at T₂ for each unit increase in echocardiography measure at T₁ in multivariable linear regression.

†P value for the association of the change in SF at T₂ for each unit increase in echocardiography measure at T₁ in multivariable linear regression.

‡Increases reflect a deterioration of circumferential strain.

BSA, body surface area;ESS, end-systolic stress;LV, left ventricular;LVIDD, LV inner dimension in diastole; LVIDS, LV inner dimension in systole.