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. 2019 Jun 25;4(4):e00070-19. doi: 10.1128/mSystems.00070-19

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Copyright © 2019 Minato et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Identification of highly conserved essential genes among virulent M. tuberculosis complex strains. (A) Strains used for comparative genomic analysis. (B) Results for pan-genome analysis by Roary. (C) Number of highly conserved genes among virulent M. tuberculosis complex. Core genes are conserved in >99% of strains, soft core genes are conserved in 95 to 99% of strains, shell genes are conserved in 15 to 95% of strains, and cloud genes are conserved in 0 to 15% of strains. (D) Numbers of genes that are essential for M. tuberculosis H37Rv survival in MtbYM rich medium and highly conserved among virulent M. tuberculosis complex strains.