Table 1.
Summary of IC50 values for ondansetron, dofetilide, and AP14145 on Kv11.1 and KCa2 channels published by our group previously or in the current study.
| Ion channel | Method | AP14145 (IC50) | Dofetilide (IC50) | Ondansetron (IC50) |
|---|---|---|---|---|
| hKCa2.2 | Manual patch clamp | 1.1 µM (Simó-Vicens et al., 2017b) | >1µM | |
| hKCa2.2 | Automated patch clamp | 60 µM (Simó-Vicens et al., 2017a) | >30 µM | |
| hKCa2.3 | Manual patch clamp | 1.1 µM (Simó-Vicens et al., 2017b) | ||
| hKCa2.3 | Automated patch clamp | 1.3 µM (Diness et al., 2017) | 90 µM (Simó-Vicens et al., 2017a) | >30 µM |
| hKv11.1 | Automated patch clamp | 71.8 µM (Diness et al., 2017) | 0.03 µM | 2.79 µM |
Values with no reference are from the present study.