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. 2019 Feb;189(2):272–282. doi: 10.1016/j.ajpath.2018.10.009

Figure 2.

Figure 2

Disruption of PPARα in hepatocyte inhibits liver regeneration after PHx. A: Representative images of hematoxylin and eosin staining of liver tissues from PparaΔHep mice and Pparafl/fl mice at 24, 32, 40, and 48 hours. The arrows refer to mitotic hepatocytes. B: Representative images of 5-bromo-2-deoxyuridine (BrdU) staining of residual liver in two groups of mice at 24, 32, 40, and 48 hours after PHx. C: BrdU-positive hepatocyte/total hepatocyte ratios per field of two groups at indicated time points. D: The ratio of liver weight/body weight (LW/BW) of the two groups at different time points. Data are expressed as means ± SD (D). n = 5 Pparafl/fl mice; n = 11 PparaΔHep mice at 24, 32, 40 and 48 hours after PHx. ∗P < 0.05, ∗∗P < 0.01 versus Pparafl/fl mice. Scale bars = 20 μm (A and B). Original magnification, ×400 (A and B).